5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol

Base Information

Chemical Name:5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol
CAS No.:107804-57-9
Molecular Formula:C₁₆H₁₁Cl₂NO₃
Molecular Weight:336.174
Hs Code.:

Synonyms:5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol

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Chemical Property of 5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol

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Technology Process of 5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol

There total 9 articles about 5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 107804-75-1
7-Allyl-5-chloro-3-(2-chloro-phenyl)-benzo[d]isoxazol-6-ol

: 107804-57-9
5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 5h; Heating;
DOI:10.1248/cpb.39.1760

Reference yield:

: 7051-13-0
1-chloro-2,4-dimethoxybenzene

: 107804-57-9
5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / AlCl₃ / 1,2-dichloro-ethane / 1) 0-5 deg C -> r.t., 2 h 2) reflux, 1h

2: NH₂OH*HCl, pyridine / 4 h / Heating

3: Ac₂O, AcONa / dimethylformamide / 3.5 h / Heating

4: 100 percent / pyridine hydrochloride / 7 h / 180 - 190 °C

5: 94 percent / K₂CO₃ / dimethylformamide / 2.5 h / 50 - 60 °C

6: 60 percent / N,N-dimethylaniline / 1 h / Heating

7: 97 percent / m-chloroperbenzoic acid / CHCl₃ / 5 h / Heating

With pyridine; aluminium trichloride; hydroxylamine hydrochloride; sodium acetate; pyridine hydrochloride; acetic anhydride; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1760

Reference yield:

: 136741-69-0
5-Chloro-3-(2-chloro-phenyl)-benzo[d]isoxazol-6-ol

: 107804-57-9
5-chloro-3-(2-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃ / dimethylformamide / 2.5 h / 50 - 60 °C

2: 60 percent / N,N-dimethylaniline / 1 h / Heating

3: 97 percent / m-chloroperbenzoic acid / CHCl₃ / 5 h / Heating

With potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1760