dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate

Base Information

Chemical Name:dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate
CAS No.:1620139-28-7
Molecular Formula:C₄₀H₃₁ClN₄O₆S
Molecular Weight:731.228
Hs Code.:

Synonyms:dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate

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Chemical Property of dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate

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Technology Process of dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate

There total 4 articles about dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 15014-25-2
malonic acid dibenzyl ester

: 1620139-42-5
C₂₃H₁₅ClN₄O₂S

: 1620139-28-7
dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.05.073

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1620139-28-7
dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: toluene; ethanol

3: dichloromethane / 20 °C

With potassium carbonate; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmcl.2014.05.073

Reference yield:

: 2148-57-4
4,7-dichloroquinazoline

: 1620139-28-7
dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: toluene; ethanol

3: dichloromethane / 20 °C

With potassium carbonate; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmcl.2014.05.073