8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide

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Chemical Name:8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide
CAS No.:1449277-14-8
Molecular Formula:C₂₃H₂₂FN₅O₂
Molecular Weight:419.458
Hs Code.:

Synonyms:8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide

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Chemical Property of 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide

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Technology Process of 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide

There total 12 articles about 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449278-70-9
8-amino-N-(azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridine-5-carboxamide

: 1759-53-1
cyclopropanecarboxylic acid

: 1449277-14-8
8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide

Guidance literature:: cyclopropanecarboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

8-amino-N-(azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridine-5-carboxamide; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

Reference yield:

: 1449278-69-6
tert-butyl 3-[[8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carbonyl]amino]azetidine-1-carboxylate

: 1449277-14-8
8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: 0.17 h / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1449277-90-0
ethyl 8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxylate

: 1449277-14-8
8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-N-methyl-1,7-naphthyridin-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / methanol / 2 h / 50 °C / Inert atmosphere

2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

4.2: 0.17 h / Inert atmosphere

With water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;