Meclizine Monohydrochloride

Base Information Edit

Chemical Name:Meclizine Monohydrochloride
CAS No.:36236-67-6
Molecular Formula:C₂₅H₂₇ClN₂*2ClH
Molecular Weight:463.878
Hs Code.:
European Community (EC) Number:252-932-4
NSC Number:757094,28728
UNII:008PUV3986
DSSTox Substance ID:DTXSID80957624
Wikidata:Q27231341
NCI Thesaurus Code:C29245
RXCUI:82041
ChEMBL ID:CHEMBL1085765
Mol file:36236-67-6.mol

Synonyms:Agyrax;Antivert;Bonamine;Bonine;Chiclida;D Vert;D-Vert;Dihydrochloride, Meclizine;DVert;Histametizyn;Hydrochloride, Meclizine;Meclizine;Meclizine Dihydrochloride;Meclizine Hydrochloride;Meclizine Monohydrochloride;Meclozine;Monohydrochloride, Meclizine;Parachloramine;Ru Vert M;Ru-Vert-M

Suppliers and Price of Meclizine Monohydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 12 raw suppliers

Chemical Property of Meclizine Monohydrochloride Edit

Chemical Property:

Refractive Index:1.6300 (estimate)
Boiling Point:495.3°Cat760mmHg
Flash Point:253.3°C
PSA：6.48000
Density:1.159g/cm³
LogP:6.23340
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:426.1629543
Heavy Atom Count:29
Complexity:448

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl
Recent ClinicalTrials:Evaluation of Meclizine Orodispersible Tablet Pharmacokinetic in Human Volunteers
Uses Medicine (antihistamine).

Technology Process of Meclizine Monohydrochloride

There total 1 articles about Meclizine Monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 620-19-9
1-chloromethyl-3-methyl-benzene

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1104-22-9,36236-67-6,163837-33-0,163837-34-1
Meclizine dihydrochloride

Guidance literature:: N-(4-chlorobenzhydryl)piperazine; With tetrabutylammomium bromide; potassium carbonate; In water; at 25 ℃;

1-chloromethyl-3-methyl-benzene; In water; at 60 ℃; for 2h;

With hydrogenchloride;

Reference yield: 90.0%

: 10273-89-9
2-(2-methylphenyl)pyridine

: 1104-22-9,36236-67-6,163837-33-0,163837-34-1
Meclizine dihydrochloride

: C₃₇H₃₇N₃

Guidance literature:: With C₁₇H₂₄N₅Ru⁽¹⁺⁾*F₆P^(1-); potassium acetate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 24h; Glovebox; Inert atmosphere;