Technology Process of N1-hydroxy-N8-(4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)phenyl)octanediamide
There total 9 articles about N1-hydroxy-N8-(4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)phenyl)octanediamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: methanol / 5 h / 20 °C / Inert atmosphere
2.1: methanol; sodium tetrahydroborate / 0.17 h
3.1: 1H-imidazole / dichloromethane / Inert atmosphere
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
5.1: trifluoroacetic acid / 0.5 h
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
7.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 5 h
7.2: pH 4 - 5
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
9.1: hydrogen / palladium on activated charcoal / methanol
With
1H-imidazole; methanol; sodium tetrahydroborate; lithium hydroxide monohydrate; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / Inert atmosphere
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
3.1: trifluoroacetic acid / 0.5 h
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
5.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 5 h
5.2: pH 4 - 5
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
7.1: hydrogen / palladium on activated charcoal / methanol
With
1H-imidazole; lithium hydroxide monohydrate; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
