[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid

Base Information

Chemical Name:[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid
CAS No.:917023-77-9
Molecular Formula:C₃₅H₄₃FO₃
Molecular Weight:530.723
Hs Code.:

Synonyms:[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid

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Chemical Property of [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid

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Technology Process of [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid

There total 11 articles about [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 917025-93-5
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid methyl ester

: 917023-77-9
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid

Guidance literature:: [4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid methyl ester; With sodium hydroxide; water; In methanol; for 5h;

With ammonium chloride; In methanol; water;

Reference yield:

: 865236-05-1
4-(1-ethyl-1-[4-(1-hydroxycyclohexylethynyl)-3-methylphenyl]propyl)-2-methylphenol

: 917023-77-9
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 0.17 h / 10 °C

2: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5 h / 85 °C

3: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h

6: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 3 h / 100 °C

7: sodium hydroxide; water / methanol / 5 h

With pyridine; 2,6-dimethylpyridine; sodium hydroxide; potassium phosphate; tetrabutyl ammonium fluoride; water; hydrogen; potassium acetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 865235-89-8
trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methylphenyl)-propyl]-2-methylphenyl ester

: 917023-77-9
[4'-(1-ethyl-1-{4-[2-(1-hydroxy-cyclohexyl)-ethyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 1.5 h / 110 °C

2: pyridine / dichloromethane / 0.17 h / 10 °C

3: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5 h / 85 °C

4: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

5: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h

7: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 3 h / 100 °C

8: sodium hydroxide; water / methanol / 5 h

With pyridine; 2,6-dimethylpyridine; sodium hydroxide; potassium phosphate; tetrabutyl ammonium fluoride; water; hydrogen; potassium acetate; triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;