5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

Base Information

Chemical Name:5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione
CAS No.:943141-64-8
Molecular Formula:C₃₅H₃₂ClNO₃S
Molecular Weight:582.163
Hs Code.:

Synonyms:5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

Suppliers and Price of 5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

There total 13 articles about 5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 943141-63-7
(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamaldehyde

: 2295-31-0
thiazoline-2,4-dione

: 943141-64-8
5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

Guidance literature:: With acetic acid; diethylamine; In toluene; for 2h; Heating;
DOI:10.1021/jm0613323

Reference yield:

: 103909-79-1
ethyl (E)-3-chloro-4-hydroxycinnamate

: 943141-64-8
5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / pyridine / CH₂Cl₂ / 20 °C

2: 91 percent / LiCl; aq. Na₂CO₃ / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating

3: 91 percent / DIBAL / CH₂Cl₂; hexane / 3 h / -78 °C

4: 72 percent / Me₂SO; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 20 °C

5: 62 percent / HOAc; NHEt₂ / toluene / 2 h / Heating

With pyridine; oxalyl dichloride; diisobutylaluminium hydride; sodium carbonate; acetic acid; dimethyl sulfoxide; diethylamine; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; hexane; dichloromethane; toluene; 2: Suzuki-Miyaura coupling / 4: Swern oxidation;
DOI:10.1021/jm0613323

Reference yield:

: 524937-24-4
(E)-ethyl 3-(3-chloro-4-(trifluoromethylsulphonyloxy)phenyl)acrylate

: 943141-64-8
5-{3-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-4-biphenyl]-(2E)-2-propenylidene}-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / LiCl; aq. Na₂CO₃ / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating

2: 91 percent / DIBAL / CH₂Cl₂; hexane / 3 h / -78 °C

3: 72 percent / Me₂SO; oxalyl chloride; Et₃N / CH₂Cl₂ / -78 - 20 °C

4: 62 percent / HOAc; NHEt₂ / toluene / 2 h / Heating

With oxalyl dichloride; diisobutylaluminium hydride; sodium carbonate; acetic acid; dimethyl sulfoxide; diethylamine; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; hexane; dichloromethane; toluene; 1: Suzuki-Miyaura coupling / 3: Swern oxidation;
DOI:10.1021/jm0613323