(RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

Base Information

Chemical Name:(RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline
CAS No.:1332661-17-2
Molecular Formula:C₂₈H₃₁N₃
Molecular Weight:409.574
Hs Code.:

Synonyms:(RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

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Technology Process of (RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

There total 5 articles about (RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1332660-85-1
(RS)-6-bromo-2-methyl-4-phenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

: 98-80-6
phenylboronic acid

: 1332661-17-2
(RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/jm200312v

Reference yield:

: 1332671-37-0
C₂₂H₂₆BrN₃O

: 1332661-17-2
(RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 16 h / 78 °C

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation

With sodium tetrahydroborate; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; 2: Suzuki coupling;
DOI:10.1021/jm200312v

Reference yield:

: 71787-43-4
N-(2-benzoyl-4-bromophenyl)acetamide

: 1332661-17-2
(RS)-2-methyl-4,6-diphenyl-3-(2-(piperidin-1-yl)ethyl)-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 1 h / 160 °C / Microwave irradiation

2: sodium tetrahydroborate / ethanol / 16 h / 78 °C

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation

With sodium tetrahydroborate; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; 3: Suzuki coupling;
DOI:10.1021/jm200312v