3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one

Base Information

Chemical Name:3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one
CAS No.:1436713-00-6
Molecular Formula:C₂₃H₂₂N₂O₃
Molecular Weight:374.439
Hs Code.:

Synonyms:3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one

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Chemical Property of 3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one

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Technology Process of 3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one

There total 7 articles about 3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1436712-97-8
5-(3-bromophenyl)-3-methoxy-5-(4-methoxyphenyl)pyrrolidin-2-one

: 1692-25-7
3-pyridylboronic acid

: 1436713-00-6
3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;
DOI:10.1021/jm3011349

Reference yield:

: 1436712-82-1
(3-bromophenyl)(4-methoxyphenyl)methanone oxime

: 1436713-00-6
3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexyl-carbodiimide; trifluoroacetic acid / benzene / 20 - 25 °C / Inert atmosphere; Cooling with ice

2: 0.67 h / 150 °C / Inert atmosphere; Microwave irradiation

3: sulfuric acid / methanol / 3 h / 60 °C / Inert atmosphere

4: molybdenum hexacarbonyl / water; acetonitrile / 3 h / 20 - 25 °C / Reflux; Inert atmosphere

5: silver(l) oxide / acetonitrile / 5 h / 20 - 40 °C / Inert atmosphere

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; silver(l) oxide; molybdenum hexacarbonyl; In 1,4-dioxane; methanol; water; acetonitrile; benzene;
DOI:10.1021/jm3011349

Reference yield:

: 1436712-88-7
C₂₀H₂₂BrNO₄S

: 1436713-00-6
3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / methanol / 3 h / 60 °C / Inert atmosphere

2: molybdenum hexacarbonyl / water; acetonitrile / 3 h / 20 - 25 °C / Reflux; Inert atmosphere

3: silver(l) oxide / acetonitrile / 5 h / 20 - 40 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; silver(l) oxide; molybdenum hexacarbonyl; In 1,4-dioxane; methanol; water; acetonitrile;
DOI:10.1021/jm3011349