Technology Process of 3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one
There total 7 articles about 3-methoxy-5-(4-methoxyphenyl)-5-(3-(pyridin-3-yl)phenyl)pyrrolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,4-dioxane; water;
at 90 ℃;
Inert atmosphere;
DOI:10.1021/jm3011349
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dicyclohexyl-carbodiimide; trifluoroacetic acid / benzene / 20 - 25 °C / Inert atmosphere; Cooling with ice
2: 0.67 h / 150 °C / Inert atmosphere; Microwave irradiation
3: sulfuric acid / methanol / 3 h / 60 °C / Inert atmosphere
4: molybdenum hexacarbonyl / water; acetonitrile / 3 h / 20 - 25 °C / Reflux; Inert atmosphere
5: silver(l) oxide / acetonitrile / 5 h / 20 - 40 °C / Inert atmosphere
6: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 90 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); sulfuric acid; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; silver(l) oxide; molybdenum hexacarbonyl;
In
1,4-dioxane; methanol; water; acetonitrile; benzene;
DOI:10.1021/jm3011349
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuric acid / methanol / 3 h / 60 °C / Inert atmosphere
2: molybdenum hexacarbonyl / water; acetonitrile / 3 h / 20 - 25 °C / Reflux; Inert atmosphere
3: silver(l) oxide / acetonitrile / 5 h / 20 - 40 °C / Inert atmosphere
4: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 90 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); sulfuric acid; potassium carbonate; silver(l) oxide; molybdenum hexacarbonyl;
In
1,4-dioxane; methanol; water; acetonitrile;
DOI:10.1021/jm3011349