6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine

Base Information

• Chemical Name: 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine
• CAS No.: 135128-67-5
• Molecular Formula: C₂₂H₂₀N₁₀O
• Molecular Weight: 440.467
• Mol file: 135128-67-5.mol

Synonyms:6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine

Chemical Property of 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine

There total 6 articles about 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-Chloro-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-ethoxy-phenyl)-4,5-dihydro-pyridazine (135128-69-7) → 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine (135128-67-5)

Guidance literature:

With sodium azide; In water; N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1246/bcsj.64.2032

Reference yield: 49.0%

[6-(4-Ethoxy-phenyl)-4-(5-hydrazino-3-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-pyridazin-3-yl]-hydrazine (135128-71-1) → 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine (135128-67-5)

Guidance literature:

With sodium nitrite; In water; acetic acid; for 1h;

DOI:10.1246/bcsj.64.2032

Reference yield:

(E)-4-(4-ethoxyphenyl)-4-oxobut-2-enoic acid (29582-31-8) → 6-(4-Ethoxy-phenyl)-8-(6-methyl-4-phenyl-4H-pyrazolo[3,4-d][1,2,3]triazol-6a-yl)-7,8-dihydro-tetrazolo[1,5-b]pyridazine (135128-67-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 46 percent / benzene / 10 h / Heating

2: 60 percent / hydrazine hydrate / ethanol / 5 h / Heating

3: 45 percent / POCl₃ / 0.5 h / Heating

4: 70 percent / hydrazine hydrate / ethanol / 5 h / Heating

5: 49 percent / NaNO₂ / H₂O; acetic acid / 1 h

With hydrazine hydrate; sodium nitrite; trichlorophosphate; In ethanol; water; acetic acid; benzene;

DOI:10.1246/bcsj.64.2032

upstream raw materials:

3-Chloro-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-ethoxy-phenyl)-4,5-dihydro-pyridazine

[6-(4-Ethoxy-phenyl)-4-(5-hydrazino-3-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-pyridazin-3-yl]-hydrazine

(E)-4-(4-ethoxyphenyl)-4-oxobut-2-enoic acid

6-(p-Ethoxyphenyl)-4-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-4,5-dihydro-3(2H)-pyridazinone