4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

Chemical Name:4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide
CAS No.:1362739-46-5
Molecular Formula:C₁₆H₁₃Cl₂FN₄O₃S₂
Molecular Weight:463.341
Hs Code.:

Synonyms:4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

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Technology Process of 4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

There total 10 articles about 4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1268830-76-7
N-(3-amino-4-chloro-2-fluorophenyl)propane-1-sulfonamide

: 1269667-58-4
4-chlorothieno[3,2-d]pyrimidine-7-carbonyl chloride

: 1362739-46-5
4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: With oxalyl dichloride; In tetrahydrofuran; for 1.5h; Inert atmosphere;
DOI:10.1021/jm300016v

Reference yield:

: 918523-47-4
benzyl 6-chloro-2-fluoro-3-(propylsulfonamido)benzoate

: 1362739-46-5
4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; potassium hydroxide / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

2.1: diphenyl phosphoryl azide; triethylamine / tetrahydrofuran / 5 h / 20 - 80 °C / Inert atmosphere

2.2: 15 h / 80 °C

3.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 55 20 °C / Inert atmosphere

With oxalyl dichloride; diphenyl phosphoryl azide; water; triethylamine; potassium hydroxide; In tetrahydrofuran;
DOI:10.1021/jm300016v

Reference yield:

: 1246223-44-8
methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate

: 1362739-46-5
4-chloro-N-(6-chloro-2-fluoro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1.25 h / 0 - 20 °C / Inert atmosphere

3: oxalyl dichloride / tetrahydrofuran / 1.5 h / 55 20 °C / Inert atmosphere

With oxalyl dichloride; lithium hydroxide monohydrate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm300016v