1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
• CAS No.: 84158-64-5
• Molecular Formula: C₂₀H₂₁N₃O₃S
• Molecular Weight: 383.471
• Mol file: 84158-64-5.mol

Synonyms:1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Chemical Property of 1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

There total 1 articles about 1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-chloro-1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylate (75020-42-7) + para-thiocresol (106-45-6) → 1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (84158-64-5)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, RT, 1 h, 2.) DMF, 80 deg C, 24 h;

DOI:10.1021/jm00368a021

Reference yield: 100.0%

1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (84158-64-5) → 1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid (84158-65-6)

Guidance literature:

With sodium hydroxide; at 85 ℃; for 3h;

DOI:10.1021/jm00368a021

Reference yield:

1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (84158-64-5) → 3-(4-Methoxy-benzyl)-7-methyl-4,4-dioxo-3,4-dihydro-4λ6-thia-1,2,3-triaza-cyclopenta[b]naphthalen-9-one (87598-53-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / 1.25 M aq. NaOH / 3 h / 85 °C

2: oxalyl chloride, DMF / CH₂Cl₂ / 2 h / Ambient temperature

3: AlCl₃ / CH₂Cl₂ / 3 h / 0 °C

4: 60 percent / KMnO₄, acetic acid / H₂O / 40 °C

With sodium hydroxide; potassium permanganate; aluminium trichloride; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In dichloromethane; water;

DOI:10.1021/jm00368a021

upstream raw materials:

ethyl 5-chloro-1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylate

para-thiocresol

Downstream raw materials:

1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carboxylic acid

3-(4-Methoxy-benzyl)-7-methyl-3H-4-thia-1,2,3-triaza-cyclopenta[b]naphthalen-9-one

1-(4-Methoxy-benzyl)-5-p-tolylsulfanyl-1H-[1,2,3]triazole-4-carbonyl chloride

3-(4-Methoxy-benzyl)-7-methyl-4,4-dioxo-3,4-dihydro-4λ⁶-thia-1,2,3-triaza-cyclopenta[b]naphthalen-9-one