Ricin.

Base Information

• Chemical Name: Ricin.
• CAS No.: 9009-86-3
• Molecular Weight: 0
• Mol file: 9009-86-3.mol

Synonyms:Agent W; Castor Bean Lectin; HSDB 3566; Proteins, ricins; Proteins, specific or class, ricins; Ricin (Ricinus communis, seeds); Ricine; Ricins; Ricinus lectin; Ricinus toxin

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Chemical Property of Ricin.

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s): Very highly toxic by ingestion; small particle in cut, abrasion, eye, or nose may prove fatal.
• Hazard Codes: Very highly toxic by ingestion; small particle in cut, abrasion, eye, or nose may prove fatal.

MSDS Files:

Useful:

• Description: Ricin is a heterodimeric ribosomeinhibiting protein consisting of an A-chain (RTA), linked by a disulphide bond to the B-chain (RTB). The total molecular weight is 66 000 Da, with the A-chain contributing 32 kDa, and the B-chain 34 kDa. The A-chain is a globular protein composed of 267 amino acids containing eight alpha helices and eight beta sheets, with the toxin’s substrate binding site located within the cleft. The B-chain is the binding lectin composed of 262 amino acids, shaped like a barbell, and has a binding site specific for membrane sugars at each end (galactose and N-acetyl galactosamine).
• Uses: As a tool in studies of cell-surface properties; experimentaly in cancer research. Ricin is a toxin found in the seeds of the castor oil plant, Ricinnus communis. The plant is cultivated commercially for its oil, but is also widespread as a weed and used as an ornamental plant. Approximately 3–5% of the waste from castor oil production is ricin. The major uses of ricin are as a chemical warfare agent, as a tool in studies of cell surface properties, and experimentally in cancer research. Ricin-A conjugate has been used experimentally in AIDS research. Low concentrations of the powders (0.3%) are marketed as a mole killer. Its preferred use seems to be as an assassin’s weapon and there are documented cases of umbrellas being used as a means of injecting ricin into human targets. It has also been found at postal facilities and mailings to a US Senator’s office. Ricin is the most well known, and ubiquitous, of the toxalbumins. Castor beans are used in the production of castor oil, a major constituent in lubricants, brake fluids, and hydraulic fluids. During the production process, 5–10% of the aqueous phase, also known as ‘waste mash,’ is recoverable as ricin. In addition, castor beans and jequirity peas are used extensively throughout Mexico and Central America for ornamental purposes in items such as necklaces, prayer or rosary beads, and the rattles in musical shakers (maracas). Other than ricin, several other toxalbumins exist in nature, including Wisteria frutescens, Abrus precatorius (precatory bean), Abrin, Wisteria sinensis (Chinese wisteria), Viscum album (European mistletoe), Phoradendron tomentosum (Christmas mistletoe), and Trichosanthes kirilowii (Chinese cucumber).