3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride

Base Information

Chemical Name:3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride
CAS No.:1414378-91-8
Molecular Formula:C₁₉H₁₃Cl₃F₃NO₂S
Molecular Weight:482.738
Hs Code.:

Synonyms:3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride

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Chemical Property of 3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride

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Technology Process of 3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride

There total 3 articles about 3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1414378-16-7
3-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid

: 1414378-91-8
3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 765-87-7
cyclohexane-1,2-dione

: 1414378-91-8
3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium / methanol / 2 h / 0 - 60 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C

3.1: thionyl chloride; pyridine / dichloromethane / 20 °C

4.1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 2.5 h / 20 °C

4.2: pH 1 / Cooling with ice

5.1: water; lithium hydroxide monohydrate / methanol / 20 °C

5.2: pH 1 / Cooling with ice

6.1: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; sodium; sodium hydroxide; lithium diisopropyl amide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1414377-97-1
3-[3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid methyl ester

: 1414378-91-8
3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 2.5 h / 20 °C

1.2: pH 1 / Cooling with ice

2.1: water; lithium hydroxide monohydrate / methanol / 20 °C

2.2: pH 1 / Cooling with ice

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; sodium hydroxide; N,N-dimethyl-formamide; In methanol; water;