(2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid

Base Information

• Chemical Name: (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid
• CAS No.: 1415566-31-2
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.303
• Mol file: 1415566-31-2.mol

Synonyms:(2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid

Chemical Property of (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid

Chemical Property:

• Boiling Point: 354.3±35.0 °C(Predicted)
• PKA: 4.07±0.20(Predicted)
• Density: 1.129±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid

There total 2 articles about (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(±)-1-tert-butoxycarbonyl-2-methylpiperidine-2-carboxylic acid (1415566-32-3) → (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid (1415566-31-2,1415566-32-3) + (2R)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid (1415566-32-3)

Guidance literature:

With Chiralcel OJ-H column; In ethanol; carbon dioxide; Resolution of racemate; liquid CO₂;

Reference yield:

(±)-1-tert-butoxycarbonyl-2-methylpiperidine-2-carboxylic acid (1415566-32-3) → (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid (1415566-31-2,1415566-32-3)

Guidance literature:

Reference yield: 49.0%

methyl (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-amino-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoate (669074-47-9) + (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid (1415566-31-2,1415566-32-3) + trifluoroacetic acid (76-05-1) → methyl N-{(2R,3R)-3-methoxy-3-[(2S)-1-{(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl(N-{[(2S)-2-methylpiperidin-2-yl]carbonyl}-L valyl)amino]heptanoyl}pyrrolidin-2-yl]-2-methylpropanoyl}-L-phenylalaninate, trifluoroacetic acid salt (1438852-61-9)

Guidance literature:

methyl (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-amino-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoate; (2S)-1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 18h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

(±)-1-tert-butoxycarbonyl-2-methylpiperidine-2-carboxylic acid

Downstream raw materials:

methyl N-{(2R,3R)-3-[(2S)-1-{(3R,4S,5S)-4-[(N-{[(2S)-1-(tert-butoxycarbonyl)-2-methylpiperidin-2-yl]carbonyl}-L-valyl)(methyl)amino]-3-methoxy-5-methylheptanoyl}pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl}-L-phenylalaninate

methyl N-{(2R,3R)-3-methoxy-3-[(2S)-1-{(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl(N-{[(2S)-2-methylpiperidin-2-yl]carbonyl}-L valyl)amino]heptanoyl}pyrrolidin-2-yl]-2-methylpropanoyl}-L-phenylalaninate, trifluoroacetic acid salt

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