(±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate

Base Information

• Chemical Name: (±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate
• CAS No.: 1585985-06-3
• Molecular Formula: C₂₂H₃₆N₂O₃
• Molecular Weight: 376.539
• Mol file: 1585985-06-3.mol

Synonyms:(±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate

Chemical Property of (±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate

There total 4 articles about (±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (±)-N-((1-benzylpiperidin-3-yl)methyl)-3-methoxypropan-1-amine (1585985-11-0) → (±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate (1585985-06-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 17h;

DOI:10.1016/j.tetlet.2014.02.034

Reference yield:

(±)-1-benzoylpiperidine-3-carboxylic acid (13850-76-5) → (±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate (1585985-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.5 h / 20 °C

1.2: 21 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 17 h / 0 - 20 °C

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2014.02.034

Reference yield:

C17H24N2O3 (1585985-10-9) → (±)-tert-butyl ((1-benzylpiperidin-3-yl)methyl)(3-methoxypropyl)carbamate (1585985-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 17 h / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2014.02.034

upstream raw materials:

(±)-1-benzoylpiperidine-3-carboxylic acid

C₁₇H₂₄N₂O₃

di-tert-butyl dicarbonate

(±)-N-((1-benzylpiperidin-3-yl)methyl)-3-methoxypropan-1-amine