N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide

Base Information

• Chemical Name: N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide
• CAS No.: 858859-62-8
• Molecular Formula: C₁₇H₁₅N₃O₃
• Molecular Weight: 309.324

Synonyms:N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide

Chemical Property of N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide

Chemical Property:

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Technology Process of N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide

There total 3 articles about N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

7-amino-4-(4-methoxy-phenyl)-1H-[1,8]naphthyridin-2-one (858859-61-7) + acetic anhydride (108-24-7) → N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide (858859-62-8)

Guidance literature:

In Dimethyl ether; under 2.5 Torr;

DOI:10.1021/ol050987f

Reference yield:

2.6-diaminopyridine (141-86-6) → N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide (858859-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 12 h / 100 °C

1.2: 38 percent / aq. H₂SO₄ / 40 - 80 °C

2.1: 86 percent / dimethyl ether / 2.5 Torr

In Dimethyl ether;

DOI:10.1021/ol050987f

Reference yield:

ethyl 4-methoxybenzoylacetate (2881-83-6) → N-[5-(4-methoxy-phenyl)-7-oxo-7,8-dihydro-[1,8]naphthyridin-2-yl]-acetamide (858859-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 12 h / 100 °C

1.2: 38 percent / aq. H₂SO₄ / 40 - 80 °C

2.1: 86 percent / dimethyl ether / 2.5 Torr

In Dimethyl ether;

DOI:10.1021/ol050987f

upstream raw materials:

7-amino-4-(4-methoxy-phenyl)-1H-[1,8]naphthyridin-2-one

acetic anhydride

2.6-diaminopyridine

ethyl 4-methoxybenzoylacetate

Downstream raw materials:

1-butyl-3-[5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-7-(4-methoxy-benzylamino)-[1,8]naphthyridin-2-yl]-urea

1-(7-amino-5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-[1,8]naphthyridin-2-yl)-3-butyl-urea

4-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-N²-(4-methoxy-benzyl)-[1,8]naphthyridine-2,7-diamine

5-{4-[2-(3,5-di-tert-butyl-phenyl)-ethoxy]-phenyl}-[1,8]naphthyridin-2-ylamine

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