8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

Base Information

Chemical Name:8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide
CAS No.:263350-45-4
Molecular Formula:C₂₄H₃₅NO₃
Molecular Weight:385.547
Hs Code.:

Synonyms:8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

Suppliers and Price of 8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

There total 4 articles about 8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96045-13-5
1-bromo-8-[(tert-butyldimethylsilyl)oxy]octane

: 263350-45-4
8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi; HMPA / tetrahydrofuran / 0.97 h / -78 °C

1.2: 71 percent / tetrahydrofuran / 7.5 h / -23 °C

2.1: 97 percent / tetra-n-butylammonium fluoride; AcOH / tetrahydrofuran / 0 °C

3.1: NaHCO₃; KBr; 2,2,6,6-tetramethylpiperidinyl-1-oxyl / Aliquat 336; NaOCl / CH₂Cl₂; H₂O / 0.5 h / 0 °C

4.1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 0.5 h / 0 °C

4.2: 72 mg / CH₂Cl₂ / 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; 1,1'-carbonyldiimidazole; potassium bromide; sodium hypochlorite; Aliquat 336; In tetrahydrofuran; dichloromethane; water; 1.1: Metallation / 1.2: Alkylation / 2.1: desilylation / 3.1: Oxidation / 4.1: Addition / 4.2: Addition;
DOI:10.1021/ja992355s

Reference yield:

: 263350-20-5
8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octan-1-ol

: 263350-45-4
8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHCO₃; KBr; 2,2,6,6-tetramethylpiperidinyl-1-oxyl / Aliquat 336; NaOCl / CH₂Cl₂; H₂O / 0.5 h / 0 °C

2.1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 72 mg / CH₂Cl₂ / 2 h

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; potassium bromide; sodium hypochlorite; Aliquat 336; In dichloromethane; water; 1.1: Oxidation / 2.1: Addition / 2.2: Addition;
DOI:10.1021/ja992355s

Reference yield:

: 263350-13-6
tert-butyl-[8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octyloxy]-dimethyl-silane

: 263350-45-4
8-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-octanoic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / tetra-n-butylammonium fluoride; AcOH / tetrahydrofuran / 0 °C

2.1: NaHCO₃; KBr; 2,2,6,6-tetramethylpiperidinyl-1-oxyl / Aliquat 336; NaOCl / CH₂Cl₂; H₂O / 0.5 h / 0 °C

3.1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 0.5 h / 0 °C

3.2: 72 mg / CH₂Cl₂ / 2 h

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; 1,1'-carbonyldiimidazole; potassium bromide; sodium hypochlorite; Aliquat 336; In tetrahydrofuran; dichloromethane; water; 1.1: desilylation / 2.1: Oxidation / 3.1: Addition / 3.2: Addition;
DOI:10.1021/ja992355s