Technology Process of Phenyl 3-hydroxy-4-methyleneoctanoate
There total 1 articles about Phenyl 3-hydroxy-4-methyleneoctanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-n-butylacrolein;
With
boron trifluoride diethyl etherate;
In
dichloromethane;
at -78 ℃;
for 0.5h;
1-phenoxy-1-trimethylsilyloxyethene;
In
dichloromethane;
at -78 - -30 ℃;
for 4h;
Further stages.;
DOI:10.1039/b010138i
- Guidance literature:
-
Multi-step reaction with 4 steps
1: iPr2NEt / CH2Cl2 / 13 h / 20 °C
2: TiCl4; PbCl2; Zn / TMEDA / tetrahydrofuran / 17 h
3: 2.20 g / TBAF; 4 Angstroem molecular sieves / tetrahydrofuran / 2.5 h
4: 59 percent / 18-crown-6; KH / tetrahydrofuran / 2 h / 20 °C
With
18-crown-6 ether; 4 A molecular sieve; tetrabutyl ammonium fluoride; titanium tetrachloride; potassium hydride; N-ethyl-N,N-diisopropylamine; lead(II) chloride; zinc;
N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/b010138i
- Guidance literature:
-
Multi-step reaction with 4 steps
1: iPr2NEt / CH2Cl2 / 13 h / 20 °C
2: TiCl4; PbCl2; Zn / TMEDA / tetrahydrofuran / 17 h
3: 2.20 g / TBAF; 4 Angstroem molecular sieves / tetrahydrofuran / 2.5 h
4: 71 percent / 18-crown-6; KH / tetrahydrofuran / 1.5 h / 20 °C
With
18-crown-6 ether; 4 A molecular sieve; tetrabutyl ammonium fluoride; titanium tetrachloride; potassium hydride; N-ethyl-N,N-diisopropylamine; lead(II) chloride; zinc;
N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/b010138i