N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride

Base Information

Chemical Name:N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride
CAS No.:1196963-27-5
Molecular Formula:C₂₇H₂₃N₇O*ClH
Molecular Weight:497.987
Hs Code.:

Synonyms:N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride

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Chemical Property of N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride

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Technology Process of N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride

There total 6 articles about N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 611-35-8
4-chloroquinoline

: 1020087-26-6
4-amino-N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]benzamide

: 1196963-27-5
N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; water; for 3h; Reflux;
DOI:10.1016/j.bmc.2013.03.033

Reference yield:

: 99-09-2
3-nitro-aniline

: 1196963-27-5
N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water; 2-ethoxy-ethanol / 16 h / Reflux

2: iron; hydrogenchloride / water; ethanol / Reflux

3: pyridine / 1,4-dioxane / 14 h / Reflux

4: iron; hydrogenchloride / water; ethanol / 14 h / Reflux

5: hydrogenchloride / water; ethanol / 3 h / Reflux

With pyridine; hydrogenchloride; iron; In 1,4-dioxane; 2-ethoxy-ethanol; ethanol; water;
DOI:10.1016/j.bmc.2013.03.033

Reference yield:

: 1020087-24-4
N⁴-(3-aminophenyl)-6-methylpyrimidine-2,4-diamine

: 1196963-27-5
N-[3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1,4-dioxane / 14 h / Reflux

2: iron; hydrogenchloride / water; ethanol / 14 h / Reflux

3: hydrogenchloride / water; ethanol / 3 h / Reflux

With pyridine; hydrogenchloride; iron; In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmc.2013.03.033