9-((phenylsulfonyl)methyl)-9H-fluorene

Base Information

• Chemical Name: 9-((phenylsulfonyl)methyl)-9H-fluorene
• CAS No.: 56954-82-6
• Molecular Formula: C₂₀H₁₆O₂S
• Molecular Weight: 320.412
• Mol file: 56954-82-6.mol

Synonyms:9-((phenylsulfonyl)methyl)-9H-fluorene

Chemical Property of 9-((phenylsulfonyl)methyl)-9H-fluorene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-((phenylsulfonyl)methyl)-9H-fluorene

There total 5 articles about 9-((phenylsulfonyl)methyl)-9H-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

PVS (5535-48-8) + [1,1'-biphenyl]-2,2'-iodonium trifluoromethanesulfonate (189999-35-7) → 9-((phenylsulfonyl)methyl)-9H-fluorene (56954-82-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; triethylamine; In 1,2-dichloro-ethane; at 100 ℃; for 15h; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.202001080

Reference yield:

2-phenylaniline (90-41-5) → 9-((phenylsulfonyl)methyl)-9H-fluorene (56954-82-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 0.17 h / 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; sodium formate / 1,2-dichloro-ethane / 15 h / 100 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;

DOI:10.1002/adsc.202001080

Reference yield:

2-iodophenylamine (615-43-0) → 9-((phenylsulfonyl)methyl)-9H-fluorene (56954-82-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran / 12 h / Reflux; Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / tetrahydrofuran; water / 0.33 h / 0 °C

2.2: 0.17 h / 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; sodium formate / 1,2-dichloro-ethane / 15 h / 100 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;

DOI:10.1002/adsc.202001080

upstream raw materials:

2-phenylaniline

2-iodobiphenyl

PVS

[1,1'-biphenyl]-2,2'-iodonium trifluoromethanesulfonate