Allyl 4-aminopiperidine-1-carboxylate

Base Information

• Chemical Name: Allyl 4-aminopiperidine-1-carboxylate
• CAS No.: 358969-71-8
• Molecular Formula: C₉H₁₆N₂O₂
• Molecular Weight: 184.238
• DSSTox Substance ID: DTXSID30373335
• Nikkaji Number: J1.530.771D
• Wikidata: Q82161491
• Mol file: 358969-71-8.mol

Synonyms:358969-71-8;4-Amino-1-N-alloc-piperidine;allyl 4-aminopiperidine-1-carboxylate;Prop-2-enyl 4-aminopiperidine-1-carboxylate;Allyl 4-Aminopiperdine-1-carboxylate;SCHEMBL19211629;DTXSID30373335;allyl4-aminopiperidine-1-carboxylate;MFCD02179415;AKOS006345222;AB11104;4-amino-1-N-alloc-piperidine, AldrichCPR;CS-0200170;4-Aminopiperidine-1-carboxylic acid allyl ester;A66004;PROP-2-EN-1-YL 4-AMINOPIPERIDINE-1-CARBOXYLATE

Chemical Property of Allyl 4-aminopiperidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.00656mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 271.1 °C at 760 mmHg
• Flash Point: 117.8 °C
• PSA: 55.56000
• Density: 1.078 g/cm³
• LogP: 1.37030
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 184.121177757
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

97% ^*data from raw suppliers

Allyl4-Aminopiperdine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CCOC(=O)N1CCC(CC1)N
• Uses: Allyl 4-Aminopiperdine-1-carboxylate has been used as a reactant for the preparation of 4-aminopiperdine analogs.

Technology Process of Allyl 4-aminopiperidine-1-carboxylate

There total 2 articles about Allyl 4-aminopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-allyloxycarbonylpiperidin-4-one (306296-67-3) → 4-amino-N-alloc-piperidine (358969-71-8)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; for 1h; Heating;

DOI:10.1016/S0040-4039(01)00755-9

Reference yield:

piperidine-4,4-diol hydrochloride (40064-34-4) → 4-amino-N-alloc-piperidine (358969-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃ / H₂O / 2 h / 5 - 20 °C

2: 78 percent / NaBH₃CN; NH₄OAc / methanol / 1 h / Heating

With ammonium acetate; sodium cyanoborohydride; potassium carbonate; In methanol; water;

DOI:10.1016/S0040-4039(01)00755-9

upstream raw materials:

1-allyloxycarbonylpiperidin-4-one

piperidine-4,4-diol hydrochloride