benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

Base Information

Chemical Name:benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate
CAS No.:1374568-54-3
Molecular Formula:C₂₇H₄₁I₂N₃O₅
Molecular Weight:741.449
Hs Code.:

Synonyms:benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

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Chemical Property of benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

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Technology Process of benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

There total 5 articles about benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: benzyl (2S)-1-{(2S)-1-[(3S)-2-hydroxy-1,1-diiodo-5-methylhexan-3-ylamino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

: 1374568-54-3
benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 15h;
DOI:10.1002/anie.201308984

Reference yield:

: 133407-82-6
N-(benzyloxycarbonyl)-leucinylleucinylleucinal

: 1374568-54-3
benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: isopropylmagnesium chloride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 15 h / 20 °C

With isopropylmagnesium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1002/ejoc.201101835

Reference yield:

: 7801-71-0
N-benzyloxycarbonyl-L-leucyl-L-leucine

: 1374568-54-3
benzyl (S)-1-{(S)-1-[(S)-1,1-diiodo-5-methyl-2-oxohexan-3-yl-amino]-4-methyl-1-oxopentan-2-ylamino}-4-methyl-1-oxopentan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 h / 20 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1.25 h / -78 - 0 °C / Inert atmosphere

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 15 h / 20 °C

With isopropylmagnesium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/anie.201308984