3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline

Base Information

Chemical Name:3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline
CAS No.:122145-43-1
Molecular Formula:C₁₉H₁₇NO₃S
Molecular Weight:339.415
Hs Code.:

3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenz<cd>indoline

Synonyms:3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline

Chemical Property:

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Technology Process of 3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline

There total 3 articles about 3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 122145-40-8
1-tosyl-3-oxo-1,3-dihydrobenzindoline

: 122145-43-1
3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline

Guidance literature:: In tetrahydrofuran; at -10 ℃; for 3h;
DOI:10.1021/jo00278a029

Reference yield:

: 122145-38-4
4-bromo-3-acryloyl-1-tosylindole

: 122145-43-1
3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / triethylamine, palladium(II)acetate, tri-o-tolylphosphine / acetonitrile / 4 h / 85 °C

2: 50 percent / tetrahydrofuran / 3 h / -10 °C

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo00278a029

Reference yield:

: 90481-79-1
4-bromo-3-(chloromercurio)-1-tosylindole

: 122145-43-1
3-hydroxy-2-methyl-1-tosyl-1,2-dihydrobenzindoline

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / hexamethylphosphoric acid triamide / 6 h / 85 °C

2: 89 percent / triethylamine, palladium(II)acetate, tri-o-tolylphosphine / acetonitrile / 4 h / 85 °C

3: 50 percent / tetrahydrofuran / 3 h / -10 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile;
DOI:10.1021/jo00278a029