5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde

Base Information

Chemical Name:5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde
CAS No.:1174754-36-9
Molecular Formula:C₂₆H₂₅F₆NOS₂Si
Molecular Weight:573.699
Hs Code.:

Synonyms:5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde

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Chemical Property of 5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde

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Technology Process of 5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde

There total 7 articles about 5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1174754-33-6
4-(4-bromo-5-(dimethoxymethyl)thiophen-2-yl)-N,N-dimethylbenzenamine

: 1174754-35-8
trimethyl(5-methyl-4-(perfluorocyclopent-1-en-1-yl)thiophen-2-yl)silane

: 1174754-36-9
5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde

Guidance literature:: 4-(4-bromo-5-(dimethoxymethyl)thiophen-2-yl)-N,N-dimethylbenzenamine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere; Schlenk technique;

trimethyl(5-methyl-4-(perfluorocyclopent-1-en-1-yl)thiophen-2-yl)silane; In tetrahydrofuran; at -78 - 20 ℃; for 17h; Inert atmosphere; Schlenk technique;
DOI:10.1039/c3ob42119h

Reference yield:

: C₂₈H₃₁F₆NO₂S₂Si

: 1174754-36-9
5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; water; at 40 ℃; for 16h; Inert atmosphere;
DOI:10.1039/b823113c

Reference yield:

: 18387-92-3
trimethyl(5-methylthiophen-2-yl)silane

: 1174754-36-9
5-(4-(dimethylamino)phenyl)-3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-5-(trimethylsilyl)thiophen-3-yl)cyclopent-1-enyl)thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / 0 °C / Inert atmosphere; Schlenk technique

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique

2.2: 17 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere; Schlenk technique

3.2: 17 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

With N-Bromosuccinimide; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1039/c3ob42119h