1-[1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]ethanone

Base Information

Chemical Name:1-[1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]ethanone
CAS No.:109113-41-9
Molecular Formula:C₁₅H₁₂N₂O₃S
Molecular Weight:300.338
Hs Code.:
DSSTox Substance ID:DTXSID101184080

Synonyms:SCHEMBL9737416;DTXSID101184080;1-[1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]ethanone;109113-41-9

Suppliers and Price of 1-[1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]ethanone

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:300.05686342
Heavy Atom Count:21
Complexity:494

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=CC2=C(N1S(=O)(=O)C3=CC=CC=C3)C=CN=C2

Technology Process of 1-[1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]ethanone

There total 9 articles about 1-[1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1N-hydrochloric acid: 1N-hydrochloric acid

: 1-benzenesulphonyl-2-lithio-1H-pyrrolo[3,2-c]pyridine

: 109113-41-9
1-benzenesulphonyl-2-acetyl-1H-pyrrolo[3,2-c]pyridine

Guidance literature:

Reference yield: 49.0%

: 1-benzenesulphonyl-2-lithio-1H-pyrrolo[3,2-c]pyridine

: 109113-41-9
1-benzenesulphonyl-2-acetyl-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: With acetic anhydride;

Reference yield:

: 1074-98-2
3-methyl-4-nitropyridine N-oxide

: 109113-41-9
1-benzenesulphonyl-2-acetyl-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / PCl₃ / 3.5 h / T < 0 deg C

2: 63 percent / dimethylformamide / 1 h / 90 °C

3: 91 percent / H₂ / 10percent Pd/C / ethanol / 14.7 - 22.07 Torr / 1) 1 h, 20 deg C, 2) 3 h, 60 deg C

4: 1) NaOH, Bu₄N*HSO₄ / 1) CH₂Cl₂, 2) 1 h

5: 1) tetramethylpiperidine-Li, tetramethylethylenediamine / 1) THF, 1 h, < -60 deg C, 2) THF, -70 to 20 deg C

With sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; tetramethylpiperidine-Li; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; phosphorus trichloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80387-2