3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine

Base Information

• Chemical Name: 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine
• CAS No.: 139887-87-9
• Molecular Formula: C₃₉H₄₄N₂O₉S
• Molecular Weight: 716.852
• Mol file: 139887-87-9.mol

Synonyms:3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine

Chemical Property of 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine

There total 5 articles about 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-thiothymidine (7236-57-9) → 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine (139887-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.5 percent / K₂CO₃ / acetone / 18 h / Ambient temperature

2: 1.) pyridine / 1.) 5 h, r.t., 2.) 90 min, r.t.

With pyridine; potassium carbonate; In acetone;

Reference yield:

Chloromethyl pivalate (18997-19-8) → 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine (139887-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.5 percent / K₂CO₃ / acetone / 18 h / Ambient temperature

2: 1.) pyridine / 1.) 5 h, r.t., 2.) 90 min, r.t.

With pyridine; potassium carbonate; In acetone;

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + acetic anhydride (108-24-7) + 4-S-pivaloyloxymethyl-4-thiothymidine (139887-83-5) → 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine (139887-87-9)

Guidance literature:

With pyridine; Yield given. Multistep reaction; 1.) 5 h, r.t., 2.) 90 min, r.t.;

upstream raw materials:

4,4'-dimethoxytrityl chloride

acetic anhydride

4-S-pivaloyloxymethyl-4-thiothymidine

5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine

Downstream raw materials:

5'-O-(4,4'-Dimethoxytrityl)-4-thiothymidine

C₄₉H₅₇N₄O₁₆PS