Technology Process of 1-(carbobenzyloxy)-2-<3,8,12,16-tetramethyl-3(E),7(E),11(E),15-heptadecatetraenyl>-4-piperidone
There total 13 articles about 1-(carbobenzyloxy)-2-<3,8,12,16-tetramethyl-3(E),7(E),11(E),15-heptadecatetraenyl>-4-piperidone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; sodium chloride;
In
dimethyl sulfoxide;
at 100 - 120 ℃;
for 6h;
DOI:10.1021/jo00036a008
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 7 h
2: 86 percent / lithium, ethylamine / tetrahydrofuran / 0.58 h / -78 °C
3: 90 percent / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature
4: pyridine / CH2Cl2 / 10 h / 0 °C
5: NaI / acetone / 4 h / Heating
7: 85 percent / NaCl, H2O / dimethylsulfoxide / 6 h / 100 - 120 °C
With
pyridine; n-butyllithium; tetrabutyl ammonium fluoride; water; lithium; ethylamine; sodium iodide; sodium chloride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/jo00036a008
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 92 percent / N-chlorosuccinimide-dimethyl sulfide complex / CH2Cl2 / 8 h / 0 °C
2: 86 percent / dimethylformamide / 10 h / Ambient temperature
3: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 7 h
4: 86 percent / lithium, ethylamine / tetrahydrofuran / 0.58 h / -78 °C
5: 90 percent / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature
6: pyridine / CH2Cl2 / 10 h / 0 °C
7: NaI / acetone / 4 h / Heating
9: 85 percent / NaCl, H2O / dimethylsulfoxide / 6 h / 100 - 120 °C
With
pyridine; n-butyllithium; N-chlorosuccinimide-dimethyl sulfide; tetrabutyl ammonium fluoride; water; lithium; ethylamine; sodium iodide; sodium chloride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00036a008
