methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate

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Chemical Name:methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate
CAS No.:1615687-50-7
Molecular Formula:C₂₉H₃₂N₄O₄S
Molecular Weight:532.663
Hs Code.:

Synonyms:methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate

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Chemical Property of methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate

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Technology Process of methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate

There total 5 articles about methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 620-19-9
1-chloromethyl-3-methyl-benzene

: 1615687-54-1
methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl)benzoate

: 1615687-50-7
methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2014.05.009

Reference yield:

: 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1615687-50-7
methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 2 h

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 3 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2014.05.009

Reference yield:

: 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

: 1615687-50-7
methyl 3-methoxy-4-(3-(5-(4-(3-methylbenzyl)piperazin-1-yl)pyridin-2-yl)-4-oxothiazolidin-2-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 3 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2014.05.009