C₉H₈ClN₃O

Base Information

• Chemical Name: C₉H₈ClN₃O
• CAS No.: 950650-35-8
• Molecular Formula: C₉H₈ClN₃O
• Molecular Weight: 209.635
• Mol file: 950650-35-8.mol

Synonyms:C₉H₈ClN₃O

Chemical Property of C₉H₈ClN₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₈ClN₃O

There total 3 articles about C₉H₈ClN₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

C9H8ClN3 → C9H8ClN3O (950650-35-8)

Guidance literature:

With Oxone; bis(benzonitrile)palladium(II) dichloride; silver nitrate; In water; acetonitrile; at 20 ℃; for 56h; regioselective reaction; Sealed tube; Schlenk technique;

DOI:10.1021/acs.orglett.8b00344

Reference yield:

4-chlorobenzaldehyde (104-88-1) → C9H8ClN3O (950650-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.17 h / 0 °C

1.2: 18 h / 40 °C

2.1: bis(benzonitrile)palladium(II) dichloride; Oxone; silver nitrate / water; acetonitrile / 56 h / 20 °C / Sealed tube; Schlenk technique

With Oxone; bis(benzonitrile)palladium(II) dichloride; silver nitrate; In tetrahydrofuran; water; acetonitrile; 2.1: |Wacker Oxidation;

DOI:10.1021/acs.orglett.8b00344

Reference yield:

3,4'-Dichloropropiophenone (3946-29-0) → C9H8ClN3O (950650-35-8)

Guidance literature:

With sodium azide; 18-crown-6 ether; In dichloromethane;

DOI:10.1016/j.tetasy.2008.03.028

upstream raw materials:

3,4'-Dichloropropiophenone

4-chlorobenzaldehyde

Downstream raw materials:

(RS)-3-azido-1-(4-chlorophenyl)propan-1-ol

Refernces

• 1、 Kamal, Ahmed,Malik, M. Shaheer,Shaik, Ahmad Ali,Azeeza, Shaik. "Synthesis of enantiomerically pure γ-azidoalcohols by lipase-catalyzed transesterification". . p. 1078 - 1083. Retrieved 2008/09/19.