6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Name:6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one
CAS No.:1221501-50-3
Molecular Formula:C₂₃H₂₄FN₃O₂
Molecular Weight:393.461
Hs Code.:

Synonyms:6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Property of 6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Technology Process of 6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

There total 5 articles about 6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943994-02-3
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one

: 1221503-66-7
4-bromo-5-(4-fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazole

: 1221501-50-3
6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1221503-82-7
4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

: 1221501-50-3
6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.5 h / 60 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 150 °C / Microwave irradiation

With di-isopropyl azodicarboxylate; caesium carbonate; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; toluene;

Reference yield:

: 29681-98-9
p-fluorobenzoylacetone

: 1221501-50-3
6-[5-(4-Fluorophenyl)-3-methyl-1-(3-methylbutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; hydrazine hydrate / methanol; water / 60 °C

2: N-Bromosuccinimide / acetonitrile / 2 h

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.5 h / 60 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 150 °C / Microwave irradiation

With hydrogenchloride; N-Bromosuccinimide; di-isopropyl azodicarboxylate; caesium carbonate; hydrazine hydrate; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; water; toluene; acetonitrile;