Technology Process of (S)-2-Amino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionic acid benzyl ester
There total 1 articles about (S)-2-Amino-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 1h;
DOI:10.1021/jm00108a006
- Guidance literature:
-
Multi-step reaction with 8 steps
1: diisopropylethylamine, diethylphosphoryl cyanide / CH2Cl2 / 18 h
2: 100 percent / 1-hydroxybenzotriazole / methanol / 18 h
3: 72 percent / diisopropylethylamine / CH2Cl2 / 18 h
4: 100 percent / diisopropylethylamine / CH2Cl2 / 1.25 h
5: 78 percent / 4-(dimethylamino)pyridine, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate / CH2Cl2 / 120 h
6: 100 percent / ammonium formate / 5percent Pd/C / dimethylformamide / 18 h
7: 65 percent / 4-(dimethylamino)pyridine, diisopropylethylamine, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide / 18 h
8: 80 percent / trifluoroacetic acid / 2 h
With
dmap; diethylphosphoryl cyanide; ammonium formate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a006
- Guidance literature:
-
Multi-step reaction with 7 steps
1: diisopropylethylamine, diethylphosphoryl cyanide / CH2Cl2 / 18 h
2: 100 percent / 1-hydroxybenzotriazole / methanol / 18 h
3: 72 percent / diisopropylethylamine / CH2Cl2 / 18 h
4: 100 percent / diisopropylethylamine / CH2Cl2 / 1.25 h
5: 78 percent / 4-(dimethylamino)pyridine, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate / CH2Cl2 / 120 h
6: 100 percent / ammonium formate / 5percent Pd/C / dimethylformamide / 18 h
7: 65 percent / 4-(dimethylamino)pyridine, diisopropylethylamine, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide / 18 h
With
dmap; diethylphosphoryl cyanide; ammonium formate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a006
