tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane

Base Information

Chemical Name:tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane
CAS No.:1356451-97-2
Molecular Formula:C₁₈H₂₉IOSi
Molecular Weight:416.418
Hs Code.:

Synonyms:tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane

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Technology Process of tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane

There total 4 articles about tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1356452-04-4
tert-butyl[(2R,3S)-5-iodo-3-methyl-1-phenylpent-4-yn-2-yloxy]dimethylsilane

: 1356451-97-2
tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane

Guidance literature:: With 2-nitrobenzenesulfonyl hydrazide; triethylamine; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 48h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201101201

Reference yield:

: 1356452-00-0
(2R,3S)-3-methyl-1-phenylpent-4-yn-2-ol

: 1356451-97-2
tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine / dichloromethane / -20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -50 °C / Inert atmosphere

2.2: 1 h / -50 - 20 °C / Inert atmosphere

3.1: 2-nitrobenzenesulfonyl hydrazide; triethylamine / tetrahydrofuran; isopropyl alcohol / 48 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; n-butyllithium; 2-nitrobenzenesulfonyl hydrazide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1002/ejoc.201101201

Reference yield:

: 1356452-02-2
tert-butyldimethyl[(2R,3S)-3-methyl-1-phenylpent-4-yn-2-yloxy]silane

: 1356451-97-2
tert-butyl[(2R,3S,Z)-5-iodo-3-methyl-1-phenylpent-4-en-2-yloxy]dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -50 °C / Inert atmosphere

1.2: 1 h / -50 - 20 °C / Inert atmosphere

2.1: 2-nitrobenzenesulfonyl hydrazide; triethylamine / tetrahydrofuran; isopropyl alcohol / 48 h / 20 °C / Inert atmosphere

With n-butyllithium; 2-nitrobenzenesulfonyl hydrazide; triethylamine; In tetrahydrofuran; hexane; isopropyl alcohol;
DOI:10.1002/ejoc.201101201