ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate

Base Information

Chemical Name:ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate
CAS No.:1616277-96-3
Molecular Formula:C₁₈H₁₄F₂N₂O₅S
Molecular Weight:408.382
Hs Code.:

Synonyms:ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate

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Chemical Property of ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate

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Technology Process of ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate

There total 10 articles about ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2,4-difluorophenyl)thioacetic acid hydrazide

: 1616277-95-2
C₁₀H₁₀O₇

: 1616277-96-3
ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate

Guidance literature:: C₁₀H₁₀O₇; With oxalyl dichloride; N,N-dimethyl-formamide; In toluene; at 0 - 20 ℃; for 2h; Inert atmosphere;

(2,4-difluorophenyl)thioacetic acid hydrazide; In chloroform; at 20 ℃; for 16h;

Reference yield:

: (2,4-difluorophenyl)thioacetic acid hydrazide

: C₁₀H₉ClO₆

: 1616277-96-3
ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate

Guidance literature:: In chloroform; at 20 ℃; for 16h;

Reference yield:

: 74530-59-9
tert-butyl 4-methoxy-3-oxobutanoate

: 1616277-96-3
ethyl 5-(5-(2,4-difluorobenzyl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-oxo-4H-pyran-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / 80 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere

2.2: 1 h / -70 °C

3.1: hydrogenchloride / ethyl acetate / 1 h / 0 - 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; toluene / 2 h / 0 - 20 °C / Inert atmosphere

5.1: chloroform / 16 h / 20 °C

With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;