(R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate

Base Information

Chemical Name:(R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate
CAS No.:1612232-94-6
Molecular Formula:C₂₃H₂₅FN₂O₄
Molecular Weight:412.461
Hs Code.:

Synonyms:(R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate

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Chemical Property of (R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate

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Technology Process of (R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate

There total 5 articles about (R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: (R)-quinuclidin-3-yl carbonochloridate

: 1612232-93-5
methyl 3-(((2-fluorophenyl)amino)methyl)benzoate

: 1612232-94-6
(R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate

Guidance literature:: With dmap; In pyridine; methanol; ethyl acetate; at 0 - 20 ℃; for 68.5h; Inert atmosphere;

Reference yield: 73.0%

: [(3R)-quinuclidin-3-yl] carbonochloridate hydrochloride

: 1612232-93-5
methyl 3-(((2-fluorophenyl)amino)methyl)benzoate

: 1612232-94-6
(R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate

Guidance literature:: With pyridine; dmap; at 0 - 20 ℃; for 68.5h; Inert atmosphere;

Reference yield:

: 348-54-9
2-Fluoroaniline

: 1612232-94-6
(R)-methyl 3-(((2-fluorophenyl)((quinuclidin-3-yloxy)carbonyl)amino)-methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 18 h / 20 °C

1.2: 3 h / 20 °C

2.1: dmap; pyridine / 68.5 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; acetic acid; In dichloromethane;