1-Iodo-4-N-propylbenzene

Base Information

• Chemical Name: 1-Iodo-4-N-propylbenzene
• CAS No.: 126261-84-5
• Molecular Formula: C9H11I
• Molecular Weight: 246.091
• Mol file: 126261-84-5.mol

Synonyms:1-Iodo-4-propylbenzene;1-Propyl-4-iodobenzene;4-Propyl-1-iodobenzene;4-Propyliodobenzene;1-iodo-4-propylbenzene;

Chemical Property of 1-Iodo-4-N-propylbenzene

Chemical Property:

• Vapor Pressure: 0.105mmHg at 25°C
• Refractive Index: 1.5790
• Boiling Point: 229.4 °C at 760 mmHg
• Flash Point: 99.1 °C
• PSA: 0.00000
• Density: 1.53 g/cm³
• LogP: 3.24370
• Sensitive.: Light Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

1-IODO-4-N-PROPYLBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Iodo-4-N-propylbenzene

There total 7 articles about 1-Iodo-4-N-propylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylpropane (103-65-1) → 1-iodo-4-n-propylbenzene (126261-84-5) + 1-iodo-2-propylbenzene (110349-09-2)

Guidance literature:

With silver(I) nitrite; iodine; In dichloromethane; for 72h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4039(01)80650-X

Reference yield:

4-propylaniline (2696-84-6) → 1-iodo-4-n-propylbenzene (126261-84-5)

Guidance literature:

4-propylaniline; With hydrogenchloride; sodium nitrite; In water; Cooling with ice;

With potassium iodide; In water;

DOI:10.1016/j.bmcl.2011.12.043

Reference yield:

para-nitrophenyl triflate (17763-80-3) → 1-iodo-4-n-propylbenzene (126261-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate monohydrate; palladium diacetate / toluene

2: palladium on activated charcoal; hydrogen / ethanol

3: hydrogenchloride; sodium nitrite / water / Cooling with ice

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; potassium phosphate monohydrate; palladium on activated charcoal; hydrogen; palladium diacetate; sodium nitrite; In ethanol; water; toluene; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.12.043

upstream raw materials:

phenylpropane

para-nitrophenyl triflate

1-nitro-4-propyl-benzene

4-propylaniline

Downstream raw materials:

1-dichloroiodanyl-4-propyl-benzene

4-propylphenylboric acid

pinacol(4-propylphenyl)boronate

5-(3-benzyloxypropyl)-3-(4-propylphenyl)-3H-[1,3,4]oxadiazol-2-one

Refernces

• 1、 -. "Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use". . . Retrieved 2008/06/13.