(R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester

Base Information

Chemical Name:(R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester
CAS No.:201804-38-8
Molecular Formula:C₂₅H₃₆O₄Si
Molecular Weight:428.644
Hs Code.:

Synonyms:(R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester

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Chemical Property of (R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester

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Technology Process of (R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester

There total 5 articles about (R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 201804-42-4
(R)-4-Acetoxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-butyric acid tert-butyl ester

: 201804-38-8
(R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at -78 ℃; for 4.5h; Yield given;
DOI:10.1016/S0957-4166(97)00560-0

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 201804-38-8
(R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, hexane, from -30 deg C to 0 deg C, 1 h, 2.) THF, 0 deg C, 2 h

2: 92 percent / H₂, (PPh₃)3RhCl / ethanol; benzene / 48 h / 3800 Torr / Ambient temperature

3: 69.5 percent / H₂O, phosphate buffer pH=7, pig panereatic lipase, aq. NaOH / diisopropyl ether / 4.33 h / 20 °C

4: imidazole / dimethylformamide / 1.) 0 deg C, 10 min, 2.) RT, 4 h

5: sodium bis(methoxyethoxy)aluminium hydride (Red-Al) / tetrahydrofuran; toluene / 4.5 h / -78 °C

With 1H-imidazole; sodium hydroxide; Wilkinson's catalyst; phosphate buffer pH=7; pig panereatic lipase; water; hydrogen; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; di-isopropyl ether; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0957-4166(97)00560-0

Reference yield:

: 201804-30-0
tert-butyl 4-(acetyloxy)-3-[(acetyloxy)methyl]but-2-enoate

: 201804-38-8
(R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂, (PPh₃)3RhCl / ethanol; benzene / 48 h / 3800 Torr / Ambient temperature

2: 69.5 percent / H₂O, phosphate buffer pH=7, pig panereatic lipase, aq. NaOH / diisopropyl ether / 4.33 h / 20 °C

3: imidazole / dimethylformamide / 1.) 0 deg C, 10 min, 2.) RT, 4 h

4: sodium bis(methoxyethoxy)aluminium hydride (Red-Al) / tetrahydrofuran; toluene / 4.5 h / -78 °C

With 1H-imidazole; sodium hydroxide; Wilkinson's catalyst; phosphate buffer pH=7; pig panereatic lipase; water; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; di-isopropyl ether; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0957-4166(97)00560-0