(1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

Base Information

Chemical Name:(1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide
CAS No.:1421014-53-0
Molecular Formula:C₂₂H₂₂FN₃O₄S
Molecular Weight:444.492
Hs Code.:

Synonyms:(1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

Chemical Property:

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Technology Process of (1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

There total 4 articles about (1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421014-38-1
(2S,3R)-2-(4-fluorophenyl)-3-methyl-1-(4-nitrophenylsulfonyl)aziridine

: 42927-57-1
15N-benzylamine

: 1421014-47-2
(1R,2R)-15N-(1-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

: 1421014-53-0
(1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.11.079

Reference yield:

: 1421117-76-1
(1R,2R)-1-chloro-1-(4-fluorophenyl)propan-2-amine

: 1421014-53-0
(1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 27 h / 20 - 50 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With triethylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.11.079

Reference yield:

: 502850-06-8
(1S,2R)-2-amino-1-(4-fluorophenyl)propan-1-ol

: 1421014-53-0
(1S,2S)-15N-(2-(benzylamino)-1-(4-fluorophenyl)propan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / toluene / 15 h / 0 - 40 °C

2: sodium hydroxide / methanol / 27 h / 20 - 50 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With thionyl chloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2012.11.079