methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate

Base Information

Chemical Name:methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate
CAS No.:938185-76-3
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate

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Chemical Property of methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate

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Technology Process of methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate

There total 1 articles about methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 460096-31-5
(Z)-N^α-benzyloxycarbonyl-Nⁱⁿ-tert-butyloxycarbonyl-2,3-dehydro-3-(indol-4'-yl)-alanine, methyl ester

: 938185-76-3
methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate

Guidance literature:: With magnesium; In methanol; at 20 ℃; for 2h;
DOI:10.1002/hlca.200790058

Reference yield: 100.0%

: 938185-76-3
methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate

: 938185-79-6
α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;
DOI:10.1002/hlca.200790058

Reference yield:

: 938185-76-3
methyl α-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]-1H-indole-4-propanoate

: α-(benzoylamino)-N,N-dimethyl-1H-indole-4-propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 1 h / 20 °C

2: 93 percent / Et₃N / acetonitrile / 3 h / -10 - 0 °C

3: 93 percent / AcOH / 16 h / 100 °C

4: 96 percent / H₂ / Pd/C / methanol / 2 h / 20 °C / 760.05 Torr

5: 95 mg / K₂CO₃ / tetrahydrofuran / 1 h / 20 °C

With lithium hydroxide; hydrogen; potassium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1002/hlca.200790058