1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

Base Information

Chemical Name:1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol
CAS No.:281661-20-9
Molecular Formula:C₃₃H₅₆O₃Si₂
Molecular Weight:556.977
Hs Code.:

1-(<i>tert</i>-butyl-dimethyl-silanyloxy)-9-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

Synonyms:1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

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Chemical Property of 1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

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Technology Process of 1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

There total 4 articles about 1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 118794-70-0
6-(t-butyldiphenylsilyloxy)hexanal

: 111849-25-3
1-bromo-3-<(tert-butyldimethylsilyl)oxy>-2,2-dimethylpropane

: 281661-20-9
1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

Guidance literature:: 1-bromo-3-<(tert-butyldimethylsilyl)oxy>-2,2-dimethylpropane; With magnesium; In tetrahydrofuran; at 0 ℃;

6-(t-butyldiphenylsilyloxy)hexanal; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jo9918450

Reference yield:

: 629-11-8
1,6-hexanediol

: 281661-20-9
1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 29 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

2.1: 83 percent / triethylamine; oxalyl chloride; DMSO / CH₂Cl₂ / 0.25 h / -60 - -50 °C

3.1: Mg / tetrahydrofuran / 0 °C

3.2: 100 percent / 1 h / 20 °C

With oxalyl dichloride; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: silylation / 2.1: Swern oxidation / 3.1: Solid phase reaction / 3.2: Grignard reaction;
DOI:10.1021/jo9918450

Reference yield:

: 121671-77-0
6-{[tert-butyl(diphenyl)silyl]oxy}hexan-1-ol

: 281661-20-9
1-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-2,2-dimethyl-nonan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / triethylamine; oxalyl chloride; DMSO / CH₂Cl₂ / 0.25 h / -60 - -50 °C

2.1: Mg / tetrahydrofuran / 0 °C

2.2: 100 percent / 1 h / 20 °C

With oxalyl dichloride; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 2.1: Solid phase reaction / 2.2: Grignard reaction;
DOI:10.1021/jo9918450