7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

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Chemical Name:7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide
CAS No.:1351236-87-7
Molecular Formula:C₂₅H₂₁BrN₆O₂S
Molecular Weight:549.451
Hs Code.:

Synonyms:7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

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Chemical Property of 7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

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Technology Process of 7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

There total 7 articles about 7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1351238-11-3
3,6-dibromopyrazine-2-carbonitrile

: 1351238-14-6
3-(2-cyanopropan-2-yl)-N-(3-(2-mercaptoacetamido)-4-methylphenyl)benzamide

: 1351236-87-7
7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: With potassium carbonate; In ethanol; at 20 - 50 ℃; for 3h;

Reference yield:

: 17231-51-5
2-amino-5-bromo-3-cyanopyrazine

: 1351236-87-7
7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 4 h / 50 °C

2: potassium carbonate / ethanol / 3 h / 20 - 50 °C

With tert.-butylnitrite; potassium carbonate; copper(ll) bromide; In ethanol; acetonitrile; 1: Sandmeyer Reaction;

Reference yield:

: 872091-85-5
methyl 3-(1-cyano-1-methylethyl)benzoate

: 1351236-87-7
7-amino-2-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 72 h

3: zinc; acetic acid / tetrahydrofuran / 1 h / 20 °C

4: 2 h / 100 °C

5: potassium carbonate / ethanol / 3 h / 20 - 50 °C

With water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 1: `;