Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

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Chemical Name:Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate
CAS No.:144750-88-9
Molecular Formula:C₂₂H₂₁N₅O₆
Molecular Weight:451.439
Hs Code.:

Synonyms:Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

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Chemical Property of Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

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Technology Process of Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

There total 2 articles about Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 144750-84-5
2-Methyl-5-bromo-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidine

: 135352-72-6
Dimethyl N-(4-ethynylbenzoyl)-L-glutamate

: 144750-88-9
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 105 ℃; for 3h;
DOI:10.1016/S0040-4020(01)80479-8

Reference yield:

: 30129-57-8
NSC 76237

: 144750-88-9
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Br₂ / H₂O / 1.) 1 h, room temperature, 2.) 1 h

2: 62 percent / NEt₃, CuI / Pd(PPh₃)4 / dimethylformamide / 3 h / 105 °C

With copper(l) iodide; bromine; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80479-8

Reference yield: 41.0%

: 144750-88-9
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate

: 144750-91-4
Dimethyl N-<4-<2-(2-methyl-4(3H)-oxo-7H-pyrazolo<3,4-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In trifluoroacetic acid; under 2585.7 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(01)80479-8