(2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester
• CAS No.: 913741-18-1
• Molecular Formula: C₂₆H₂₄FN₃O₄S₂
• Molecular Weight: 525.625
• Mol file: 913741-18-1.mol

Synonyms:(2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester

Chemical Property of (2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester

There total 7 articles about (2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate (335255-43-1) + 6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carboxylic acid (913741-16-9) → (2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester (913741-18-1)

Guidance literature:

With (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

di-tert-butyl [2-(ethoxycarbonyl)-1-benzothien-6-yl]malonate (913738-98-4) → (2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester (913741-18-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 4 °C

1.2: 4 h / 4 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.3: 2 h / Heating / reflux

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.33 h

3.2: 1 h

4.1: methanol; lithium hydroxide; water / tetrahydrofuran

5.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With methanol; lithium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; oxalyl dichloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

6-(carboxy-fluoro-methyl)-benzo[b]thiophene-2-carboxylic acid ethyl ester (913741-14-7) → (2-{[6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carbonyl]-amino}-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester (913741-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.33 h

1.2: 1 h

2.1: methanol; lithium hydroxide; water / tetrahydrofuran

3.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With methanol; lithium hydroxide; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate

6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carboxylic acid

di-tert-butyl [2-(ethoxycarbonyl)-1-benzothien-6-yl]malonate

6-(carbamoyl-fluoro-methyl)-benzo[b]thiophene-2-carboxylic acid ethyl ester