(2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:859235-95-3
Molecular Formula:C₂₆H₃₇N₃O₇
Molecular Weight:503.596
Hs Code.:

(2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 4 articles about (2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-propionic acid methyl ester; hydrochloride

: 802911-23-5
(2S,4R)-(N-tert-butyloxycarbonyl)-4-(Z)-propenylproline

: 859235-95-3
(2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/chem.200400977

Reference yield:

: 859235-82-8
(R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-propionic acid

: 859235-95-3
(2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 26 mg / SOCl₂ / 24 h / 20 °C

2: 10 mg / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride; 7-aza-1-hydroxybenzotriazole; 2,4,6-trimethylpyridine / CH₂Cl₂ / 16 h / 20 °C

With 2,4,6-trimethyl-pyridine; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1002/chem.200400977

Reference yield:

: 859235-81-7
MeZ-(R)-Asn-OH

: 859235-95-3
(2S,4R)-2-[(R)-2-Methoxycarbonyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / aq. iodobenzene bis(trifluoroacetate); pyridine / dimethylformamide / 5 h / 20 °C

2: 26 mg / SOCl₂ / 24 h / 20 °C

3: 10 mg / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride; 7-aza-1-hydroxybenzotriazole; 2,4,6-trimethylpyridine / CH₂Cl₂ / 16 h / 20 °C

With pyridine; 2,4,6-trimethyl-pyridine; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200400977