3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

Base Information

Chemical Name:3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile
CAS No.:105116-40-3
Molecular Formula:C₁₅H₂₀N₂O₃
Molecular Weight:276.335
Hs Code.:

Synonyms:3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

Suppliers and Price of 3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

There total 5 articles about 3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 105116-40-3
3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide

2: diisobutylaluminium hydride / methanol

3: sodium hydrogencarbonate

With diisobutylaluminium hydride; sodium hydrogencarbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml300197h

Reference yield:

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

: 105116-40-3
3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / methanol

2: sodium hydrogencarbonate

With diisobutylaluminium hydride; sodium hydrogencarbonate; In methanol;
DOI:10.1021/ml300197h

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 105116-40-3
3(S),2(R)-N-[(1,1-dimethylethoxy)carbonyl]-3-amino-2-hydroxy-4-phenylbutyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato) europium(III) (Eu(fod)3) / CH₂Cl₂ / -40 °C

2: 1N HCl / tetrahydrofuran

With hydrogenchloride; tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III); In tetrahydrofuran; dichloromethane;
DOI:10.1246/cl.1992.1169