O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-N^α-methyl-N-(3-phenylpropyl)-D-alanylamide

Base Information

• Chemical Name: O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-N^α-methyl-N-(3-phenylpropyl)-D-alanylamide
• CAS No.: 111633-09-1
• Molecular Formula: C₃₄H₄₉N₃O₇
• Molecular Weight: 611.779

Synonyms:O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-N^α-methyl-N-(3-phenylpropyl)-D-alanylamide

Chemical Property of O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-N^α-methyl-N-(3-phenylpropyl)-D-alanylamide

Chemical Property:

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Technology Process of O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-N^α-methyl-N-(3-phenylpropyl)-D-alanylamide

There total 4 articles about O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-N^α-methyl-N-(3-phenylpropyl)-D-alanylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Phenylpropan-1-amine (2038-57-5) → O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-Nα-methyl-N-(3-phenylpropyl)-D-alanylamide (111633-09-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NMM / CH₂Cl₂ / 1.) -55 deg C - RT, 2.) RT, 1.5 h

2: H₂ / 10percent Pd/C / methanol / 25 °C / 3102.9 Torr

3: NMM / CH₂Cl₂ / 1.) -55 deg C - RT, 2.) RT, 1.5 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

Methyl-[(R)-1-(3-phenyl-propylcarbamoyl)-ethyl]-carbamic acid benzyl ester (101488-45-3) → O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-Nα-methyl-N-(3-phenylpropyl)-D-alanylamide (111633-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 25 °C / 3102.9 Torr

2: NMM / CH₂Cl₂ / 1.) -55 deg C - RT, 2.) RT, 1.5 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

isobutyl chloroformate (543-27-1) → O-(isobutoxycarbonyl)-Boc-2,6-dimethyl-DL-tyrosyl-Nα-methyl-N-(3-phenylpropyl)-D-alanylamide (111633-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 5A molecular sieves, N-methylmorpholine / 1.) CH₂Cl₂, a) -15 deg C - 5 deg C, b) 5 deg C - -60 deg C, 2.) CH₂Cl₂, 0 deg C, 30 min

2: NMM / CH₂Cl₂ / 1.) -55 deg C - RT, 2.) RT, 1.5 h

With 4-methyl-morpholine; 5A molecular sieve; In dichloromethane;

upstream raw materials:

N^α-methyl-N-(3-phenylpropyl)-D-alaninamide

3-Phenylpropan-1-amine

Methyl-[(R)-1-(3-phenyl-propylcarbamoyl)-ethyl]-carbamic acid benzyl ester

isobutyl chloroformate

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