(2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

Base Information

Chemical Name:(2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal
CAS No.:908290-17-5
Molecular Formula:C₁₈H₂₅NO₃
Molecular Weight:303.401
Hs Code.:

Synonyms:(2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

Suppliers and Price of (2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

Chemical Property:

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Technology Process of (2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

There total 2 articles about (2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 908290-15-3
methyl (2S,3aS,7aS)-1-benzyl-6-oxooctahydroindole-2-carboxylate ethylene acetal

: 908290-17-5
(2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jo060592p

Reference yield:

: 181649-60-5
methyl (2S,3aS,7aS)-1-benzyl-6-oxo-octahydroindole-2-carboxylate

: 908290-17-5
(2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

Guidance literature:: Multi-step reaction with 2 steps

1: TsOH / toluene / 4 h / Heating

2: 441 mg / LiBH₄ / tetrahydrofuran / 24 h / 20 °C

With lithium borohydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jo060592p

Reference yield: 77.0%

: 908290-17-5
(2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal

: (3R,4aS,8aS)-1-benzyl-3-hydroxy-7-oxodecahydroquinoline ethylene acetal

Guidance literature:: (2S,3aS,7aS)-1-benzyl-2-hydroxymethyl-6-oxooctahydroindole ethylene acetal; With trifluoroacetic anhydride; In tetrahydrofuran; at -78 ℃; for 3h;

With triethylamine; In tetrahydrofuran; for 20h; Heating;

With sodium hydroxide; In tetrahydrofuran; water; for 3h;
DOI:10.1021/jo060592p