(1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide

Base Information

• Chemical Name: (1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide
• CAS No.: 350507-29-8
• Molecular Formula: C₂₅H₃₄N₂O₂
• Molecular Weight: 394.557
• Mol file: 350507-29-8.mol

Synonyms:(1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide

Chemical Property of (1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide

There total 3 articles about (1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

isopropylmagnesium chloride (1068-55-9) + N-[(1R,2S)-2-(N,N-Diethylcarbamoyl)-2-phenylcyclopropylmethylene]benzylamine N-oxide (350507-27-6,288627-96-3) → (1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide (350507-29-8)

Guidance literature:

N-[(1R,2S)-2-(N,N-Diethylcarbamoyl)-2-phenylcyclopropylmethylene]benzylamine N-oxide; With magnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h;

isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 8h; Further stages.;

DOI:10.1039/b008230i

Reference yield:

N-benzylhydroxylamine hydrochloride (29601-98-7) → (1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide (350507-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 93 percent / molecular sieves 4 Angstroem / CH₂Cl₂ / 1 h / 20 °C

2.1: MgBr₂ / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

2.2: 77 percent / diethyl ether; tetrahydrofuran / 8 h / -78 °C

With 4 A molecular sieve; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1039/b008230i

Reference yield:

(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide (172016-00-1) → (1S,2R)-1-Phenyl-2-[(S)-1-(N-benzyl-N-hydroxyamino)-2-methylpropyl]-N,N-diethylcyclopropanecarboxamide (350507-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 93 percent / molecular sieves 4 Angstroem / CH₂Cl₂ / 1 h / 20 °C

2.1: MgBr₂ / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

2.2: 77 percent / diethyl ether; tetrahydrofuran / 8 h / -78 °C

With 4 A molecular sieve; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1039/b008230i

upstream raw materials:

isopropylmagnesium chloride

N-[(1R,2S)-2-(N,N-Diethylcarbamoyl)-2-phenylcyclopropylmethylene]benzylamine N-oxide

N-benzylhydroxylamine hydrochloride

(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide