(2R,6R)-2,6-Dimethylmorpholine

Base Information

• Chemical Name: (2R,6R)-2,6-Dimethylmorpholine
• CAS No.: 6485-45-6
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Hs Code.: 2934999090
• European Community (EC) Number: 613-701-7,878-140-4
• UNII: S632XG138S
• DSSTox Substance ID: DTXSID101308806
• Nikkaji Number: J3.483.824K
• Wikidata: Q27288706
• Mol file: 6485-45-6.mol

Synonyms:(2R,6R)-2,6-Dimethylmorpholine;171753-74-5;trans-2,6-Dimethylmorpholine;6485-45-6;(2R,6R)-2,6-Dimethyl-morpholine;Morpholine, 2,6-dimethyl-, (2R,6R)-;Morpholine, 2,6-dimethyl-, (2R-trans)-;2,6-Dimethylmorpholine, (2R,6R)-;(2R-Trans)-2,6-dimethylmorpholine;UNII-S632XG138S;S632XG138S;Morpholine, 2,6-dimethyl-, (2R,6R)-rel-;MFCD18250270;trans 2,6-dimethylmorpholine;SCHEMBL579356;2alpha,6beta-Dimethylmorpholine;(R,R)-2,6-dimethylmorpholine;HNVIQLPOGUDBSU-PHDIDXHHSA-N;DTXSID101308806;AMY19631;AKOS016843330;rac-(2R,6R)-2,6-dimethylmorpholine;AC-31124;DS-16818;CS-0088046;EN300-3086679;EN300-5256374;A853166;A881911;Q27288706;Trans 2,6-dimethyl morpholine

Chemical Property of (2R,6R)-2,6-Dimethylmorpholine

Chemical Property:

• Vapor Pressure: 4.602mmHg at 25°C
• Refractive Index: 1.406
• Boiling Point: 146.599 °C at 760 mmHg
• PKA: 9.04±0.60(Predicted)
• Flash Point: 48.889 °C
• PSA: 21.26000
• Density: 0863 g/cm³
• LogP: 0.71200
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Chloroform (Slightly), Water (Slightly)
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 66.9

Purity/Quality:

99.9% ^*data from raw suppliers

trans-2,6-Dimethylmorpholine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CNCC(O1)C
• Isomeric SMILES: C[C@@H]1CNC[C@H](O1)C
• Uses: trans-2,6-Dimethylmorpholine is used as a reagent in the synthesis of 4-Amino-5-chloro-2-methoxybenzoates as agonists and antagonists for 5-HT4 receptors. Also a reagent in the synthesis of trans-Amorolfine.

Technology Process of (2R,6R)-2,6-Dimethylmorpholine

There total 17 articles about (2R,6R)-2,6-Dimethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

cis-2,6-dimethylmorpholine propionate → cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8)

Guidance literature:

With sodium hydroxide; pH=14; Reagent/catalyst;

Reference yield: 80.0%

2,6-dimethyl morpholine (141-91-3) → cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8)

Guidance literature:

2,6-dimethyl morpholine; With acetic acid; In ethyl acetate; at -2 - 40 ℃;

With sodium hydroxide; pH=14; Reagent/catalyst; Solvent; Temperature;

Reference yield: 80.0%

C6H11NO2 → (2S,6S)-2,6-Dimethyl-morpholin-3-one (117465-51-7) + cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-0034-1379641

upstream raw materials:

2,6-dimethyl morpholine

diisopropanolamine

Downstream raw materials:

7-chloro-2-((2S,6R)-2,6-dimethyl-morpholin-4-yl)-4-morpholin-4-yl-pyrido[2,3-d]pyrimidine

5-bromo-2-(cis-2,6-dimethylmorpholin-4-yl)benzaldehyde

10-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-4,5-dihydro-8-phenyl-7H-thieno<2,3-a>quinolizin-7-one

10-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-8-phenyl-7H-thieno<2,3-a>quinolizin-7-one