Technology Process of Allyl (rac)-4-[4-cyano-2-((2-hydroxyethyl)sulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate
There total 6 articles about Allyl (rac)-4-[4-cyano-2-((2-hydroxyethyl)sulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
allyl acetoacetate; 3-[(2-hydroxyethyl)sulfonyl]-4-formylbenzonitrile; N-(3-trifluoromethylphenyl)urea;
With
triethyl phosphate; phosphorus pentoxide;
In
tert-butyl methyl ether;
for 2h;
Inert atmosphere;
Reflux;
at 90 ℃;
for 5h;
Neat (no solvent);
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Reflux; Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C
4.1: water; pyridinium p-toluenesulfonate / acetone / 0.08 h / 160 °C / Microwave irradiation
5.1: phosphorus pentoxide; triethyl phosphate / tert-butyl methyl ether / 2 h / Inert atmosphere; Reflux
5.2: 5 h / 90 °C / Neat (no solvent); Inert atmosphere
With
triethyl phosphate; phosphorus pentoxide; water; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / Inert atmosphere; Reflux
1.2: 1 h / 20 °C
2.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Reflux; Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C
5.1: water; pyridinium p-toluenesulfonate / acetone / 0.08 h / 160 °C / Microwave irradiation
6.1: phosphorus pentoxide; triethyl phosphate / tert-butyl methyl ether / 2 h / Inert atmosphere; Reflux
6.2: 5 h / 90 °C / Neat (no solvent); Inert atmosphere
With
triethyl phosphate; phosphorus pentoxide; water; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide dimethyl acetal; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetone; toluene;
